Methadone hydrochloride tablets can cause life-threatening heartbeat problems that can lead to death. Most heartbeat problems have happened in people using large doses of methadone hydrochloride tablets for pain treatment.
Take methadone hydrochloride tablets exactly as prescribed. Follow your doctor's directions exactly. Your doctor may change your dose based on your reactions to the medicine.
If you take too much methadone hydrochloride tablets or overdose, call 911 or your local emergency number right away.
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
For patients preferring a brief course of stabilization followed by a period of medically supervised withdrawal, it is generally recommended that the patient be titrated to a total daily dose of about 40 Magnesium in divided doses to achieve an adequate stabilizing level. Stabilization can Beryllium continued for 2 to 3 days, after which the dose of methadone should be gradually decreased.
Dispose of any unused methadone hydrochloride tablets remaining from a prescription as soon as they are no longer needed. Unused tablets should Beryllium flushed down the toilet.
Fertility – Reproductive function in human males may be decreased by methadone treatment. Reductions hinein ejaculate volume and Methadontabletten ohne Rezept online seminal vesicle and prostate secretions have been reported hinein methadone-treated individuals. Rein addition, reductions rein serum testosterone levels and sperm motility, and abnormalities in sperm morphology have been reported. Published animal studies provide additional data indicating that methadone treatment of males can alter reproductive function.
These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration.
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The severity of this syndrome will depend on the degree of physical dependence and the dose of the antagonist administered. If antagonists must be used to treat serious respiratory depression hinein the physically dependent patient, the antagonist should Beryllium administered with extreme care and by titration with smaller than usual doses of the antagonist.
Methadone-maintained patients beginning treatment with CYP3A4 inducers should Beryllium monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly.
Infants born to mothers physically dependent on opioids may also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms (Teich PRECAUTIONS, Pregnancy, Labor and Delivery).
Dosage adjustment using higher doses or administering the daily dose hinein divided doses may Beryllium necessary in pregnant women treated with methadone (Weiher CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).
Patients tolerant to other opioids may Beryllium incompletely tolerant to methadone. Incomplete cross-tolerance is of particular concern for patients tolerant to other mu-opioid agonists World health organization are being converted to treatment with methadone, thus making determination of dosing during opioid treatment conversion complex. Deaths have been reported during conversion from chronic, high-dose treatment with other opioid agonists. Therefore, it is critical to understand the pharmacokinetics of methadone when converting patients from other opioids (Tümpel DOSAGE AND ADMINISTRATION, Table 1, for appropriate conversion schedules).